ABSTRACTS

  • admin admin

Abstract

Background: Excessive intraoperative bleeding is associated with significant morbidity and mortality. The authors and others have shown that fibrin monomer allows preoperative risk stratification for intraoperative blood loss, likely due to an imbalance between available factor XIII and prothrombin conversion. The authors hypothesized that the use of factor XIII (30 U/kg) would delay the decrease of clot firmness in high-risk patients.

Results: Twenty-two patients were evaluable for a planned interim analysis. For the primary outcome parameter maximum clot firmness, patients receiving factor XIII showed a nonsignificant 8% decrease, and patients receiving placebo lost 38%, a highly significantly difference between the two groups (P = 0.004). A reduction in the nonprimary outcome parameters fibrinogen consumption (-28%, P = 0.01) and blood loss (-29%, P = 0.041) was also observed in the factor XIII group. Three patients experienced adverse events that seemed unrelated to factor XIII substitution. The trial was stopped early after a planned interim analysis with the primary endpoint reached.

Published
05-24-2019
How to Cite
admin, admin. (2019). ABSTRACTS. Anaesthesia, Pain & Intensive Care. Retrieved from https://apicareonline.com/index.php/APIC/article/view/781
Section
ABSTRACTS

Most read articles by the same author(s)

<< < 4 5 6 7 8 9 10 11 > >>