Evaluation of clinical effectiveness of three different sedation protocols (intravenous propofol vs. ketamine vs. ketofol) in anxious children

Abstract

Aim: The aim of this prospective randomized blinded study was to evaluate clinical effectiveness of three different sedation protocols (intravenous propofol vs. ketamine vs ketofol) in children scheduled for dental treatment.
Methodology: Seventy five ASA I patients were enrolled; were randomly selected from 6-12 years aged children with documented high anxiety level  and were randomly divided into 3 groups: ketamine treated group (Group K) – received a priming dose of 1 mg/kg, followed by continuous infusion dose of 50-60 µg/kg/min, propofol treated group (Group P) – received priming dose of 2 mg/kg, followed by continuous infusion dose of 70-90 µg/kg/min, and ketamine plus propofol treated group (ketofol) (Group KP) – which received priming dose of 0.6 mg/kg, followed by continuous infusion dose of 40-60 µg/kg/min. During the study period, vital signs of children, the level of sedation using BIS monitor and time interval needed for full recovery were recorded every 5 min. The levels of changing anxiety were measured using Children’s Fear Survey Schedule – Dental Subscale (CFSS-DS) and face version of the Modified Child Dental Anxiety Scale (MCDAS_f).