Comparison of clonidine versus midazolam in monitored anesthesia care during ENT surgery– A prospective, double blind, randomized clinical study

  • Indira Kumari Department of Anesthesiology, RNT Medical College, Udaipur - Rajasthan-13001(India)
  • Udita Naithni Department of Anesthesiology, RNT Medical College, Udaipur - Rajasthan-13001(India)
  • Vikram Bedi Department of Anesthesiology, RNT Medical College, Udaipur - Rajasthan-13001(India)
  • Sapna Gupta Department of Anesthesiology, RNT Medical College, Udaipur - Rajasthan-13001(India)
  • Rajesh Gupta Department of Anesthesiology, RNT Medical College, Udaipur - Rajasthan-13001(India)
Keywords: Monitored anaesthesia care, Clonidine, Midazolam, ENT surgery, Bleeding

Abstract

Background: Monitored anaesthesia care (MAC) typically involves administration of local anaesthesia in combination with IV sedatives, anxiolytic and/or analgesic drugs which is a common practice during various ENT surgical procedures.

Aims: To compare the effectiveness and safety profile of clonidine against midazolam as an intravenously administered agent for MAC.

Study design: Randomized, double blind, prospective study.

Methodology: Sixty patients undergoing ENT surgery under MAC were divided into two groups of 30 patients each. The patients in Group C received clonidine 2 mcg/kg IV and in Group M received midazolam 20 mcg/kg IV over 10 min. Ramsay sedation score, requirement of intraoperative rescue sedation (propofol) and analgesic (diclofenac infusion), postoperative visual analogue score & analgesic requirement (tramadol), adverse effects, recovery profile (Aldrete Score) and satisfaction scores of patients and surgeon were recorded. Data were analysed by chi-square, student t test and analysis of variance using Epi info 6 with p value <0.05 as significant.

Published
02-03-2019
How to Cite
Kumari, I., Naithni, U., Bedi, V., Gupta, S., & Gupta, R. (2019). Comparison of clonidine versus midazolam in monitored anesthesia care during ENT surgery– A prospective, double blind, randomized clinical study. Anaesthesia, Pain & Intensive Care, 157-154. Retrieved from https://apicareonline.com/index.php/APIC/article/view/509
Section
Original Articles