Comparison of hemodynamic stability and recovery profile with sevoflurane as inhalational agent versus propofol as total intravenous anesthesia during laparoscopic surgeries

Abstract

Background and Aim: An ideal day care anesthetic agent should have rapid smooth induction, hemodynamic stability and provide rapid recovery with minimal intra-operative and post-operative side effects. Both propofol and sevoflurane meet these criteria. The present study investigated the hemodynamic stability and recovery profile while maintaining anesthesia with sevoflurane as inhalational agent versus propofol as total intravenous anesthesia during laparoscopic surgeries.
Methodology: This was a prospective study conducted for one year at our hospital. Using convenient sampling technique, a total of 50 adult patients of American Society of Anesthesiologists (ASA) physical status I or II, aged between 18-60 years, of either sex, who were scheduled for elective day care surgeries of less than 2-hour duration under general anesthesia were selected for the study after informed consent. All the patients were randomly allocated into one of the two groups using computer generated random number table. Group-S received induction with propofol and maintenance with sevoflurane, while Group-P was induced and maintained with propofol only. Hemodynamic and recovery profile were then compared.
Data were expressed as percentages and proportions or mean and standard deviation. The differences between two groups were analysed using unpaired t-test while categorical variables were analysed using chi-square test. All the statistical tests were performed in Epi Info 3.5.1 software by CDC, USA.⁶  p < 0.05 was considered as statistically significant while p < 0.01 was considered as statistically highly significant.
Results: The baseline demographic analysis showed that the two groups did not differ significantly in age, weight, sex, ASA grade and operative times. During the course of surgery, heart rate was significantly low in Group-P at 45 to 60 min than in Group-S. Systolic and diastolic blood pressure were significantly low during maintenance of anesthesia with propofol as compared to sevoflurane. Group-S showed significantly shorter time for spontaneous eye opening and recalling names and recognizing surroundings. Post-operative nausea and vomiting was significantly low in Group-P.