A comparison between intravenous metoprolol and labetalol in prevention of cardiovascular stress response to laryngoscopy and intubation

  • Nishee R Swami Department of Anesthesiology and Critical Care, Pravara Institute of Medical Sciences, Loni 413736 (India)
  • Vaishalee K Badhe Department of Anesthesiology and Critical Care, Pravara Institute of Medical Sciences, Loni 413736 (India)
  • Vaishali V. Deshpande Department of Anesthesiology, Seth Nandlal Dhoot Hospital, Aurangabad (India)
  • Vaijayanti K. Badhe Department of Anesthesiology, Seth Nandlal Dhoot Hospital, Aurangabad (India)
  • Shidhaye Ramchandra Vinayak Head, Department of Anesthesiology, Seth Nandlal Dhoot Hospital, Aurangabad (India)
Keywords: Labetalol, Metoprolol, Presser response, Laryngoscopy, Tracheal intubation

Abstract

Introduction: A prospective, randomized, double blind, clinical study was designed to compare intravenous metoprolol 30 µg/kg versus intravenous labetalol 0.2 mg/kg single dose given 5 min prior to intubation in for prevention of cardiovascular stress response to laryngoscopy and intubation in patients undergoing spine surgeries under general anesthesia.
Methodology: Sixty ASA grade I patients of either sex , comprising age group of 25-50 years , undergoing elective spine surgeries under general anesthesia were randomly distributed in two equal groups. Inj metoprolol hydrochloride 30 µg/kg in Group M and inj labetalol 0.2 mg/kg in Group L respectively were given intravenously 5 min prior to induction. Heart rate, systolic, diastolic and MBP recorded at different time intervals before and after intubation.
Results: Significant rise noted in heart rate, systolic, diastolic and MBP immediately after intubation in both groups though less in Group L that remained up to 2 min; returned to baseline between 2 to 5 min and became significantly lower than baseline at 5 min and onwards.
Conclusion: Labetalol is superior to metoprolol in attenuating the cardiovascular stress response to laryngoscopy and intubation.

Published
01-18-2019
How to Cite
Swami, N. R., Badhe, V. K., Deshpande, V. V., Badhe, V. K., & Vinayak, S. R. (2019). A comparison between intravenous metoprolol and labetalol in prevention of cardiovascular stress response to laryngoscopy and intubation. Anaesthesia, Pain & Intensive Care, 22(2), 180-186. Retrieved from https://apicareonline.com/index.php/APIC/article/view/45
Section
Original Articles