Attenuation of pressor response to laryngoscopy and intubation – a comparative study between two doses of gabapentin in patients undergoing laparoscopic cholecystectomy

Abstract

Background: Laryngoscopy and tracheal intubation increase blood pressure (BP) and heart rate (HR). The aim of the present study was to investigate the effect of gabapentin given before operation on the hemodynamic response to laryngoscopy and intubation in patients undergoing laparoscopic cholecystectomy.
Methodology: 90 ASA I and II patients undergoing elective laparoscopic cholecystectomy were randomly allocated to three groups of 30 each. Group C received placebo drug; group G6 received gabapentin 300 mg night before surgery and 300 mg at 6:00 AM on the day of surgery; group G9 received gabapentin 300 mg night before surgery and 600 mg at 6:00 AM on the day of surgery. Anesthesia was induced with inj. thiopentone and inj. rocuronium. Heart rate, systolic BP, diastolic BP and mean arterial pressure were recorded as baseline, after induction, at tracheal intubation (0 min.); and then at 1, 3, 5, 10, 15 min following tracheal intubation.
Results: MAP was significantly lower in G9 group as compared to the control group at 0, 1, 3, 5, 10 and 15 minutes. Heart rate did not differ amongst the three groups at any time interval.
Conclusions: Gabapentin, under present study design, attenuates the pressor response but not tachycardia associated with laryngoscopy and intubation.
Citation: Aggarwal S, Baduni N, Jain A. Attenuation of pressor response to laryngoscopy and intubation – a comparative study between two doses of gabapentin in patients undergoing laparoscopic cholecystectomy. Anaesth Pain & Intensive Care 2015;19(1):33-36