Highlighting the critical care innovations against severe dengue: mortality insights charting the next frontier

Abstract

Severe dengue has become one of the largest health issues globally, recording more than 6 million cases and more
than 20,000 deaths in 2024 alone. Although there is an improvement in vaccines, critical care interventions, timely,
correct and resource sensitive remain pivotal towards ensuring a reduced death toll at the acute stage. The current
trend of point of care Endothelial biomarkers, ultrasound guided resuscitation and AI-based shock prediction systems
have reshaped the already in place model of the dengue management system into a precision guided system. The
technologies help clinicians detect plasma leakage earlier, predict hemodynamic failure and tailor fluid treatment
more precisely and eventually preventing cases of preventable organ failure and death. This editorial suggests that
there is an emerging paradigm of precision critical care in dengue and the subsequent steps to convert innovation
into survival.
Keywords: Severe Dengue, Critical Care, Plasma Leakage, Hemodynamic Monitoring, Endothelial Biomarkers,
Ultrasound-Guided Resuscitation, Predictive Analytics, AI-Assisted Triage
Citation: Nasar S. Highlighting the critical care innovations against severe dengue: mortality insights charting the
next frontier. Anaesth. pain intensive care 2026;30(1):4-6. DOI: 10.35975/apic.v30i1.3095
Received: August 17, 2025; Revised: September 05, 2025; Accepted: September 06, 2025