Effectiveness of convalescent plasma therapy for COVID-19 patients infected with variants of concerns

  • Eighty Mardiyan Kurniawati
  • Innas Safira Putri
  • Deandra Maharani Widiatmaja
  • Venansya Maulina Praba
  • Visuddho Visuddho
  • Faida Ufaira Prameswari
  • Marsha Zahrani
  • Felix Nugraha Putra
  • David Nugraha
  • Antonio Ayrton Widiastara
Keywords: Convalescent plasma therapy, COVID-19, Variants of Concern

Abstract

COVID-19 cases in Indonesia seemed to be increasing by each passing day at the time of writing this review, more positive cases discovered than the recovered ones. With the highest rank within all ASEAN countries, and also a home of many variants of COVID-19, Indonesia had become a break off destination to others. Along with the problem associated with the pandemic, which all people had to face, the purpose of this review is to elaborate the use of convalescent plasma therapy on treatment against COVID-19, especially its different variants. We overview the evidence that we obtained from several databases using specific keywords. A large amount of evidence points out that the convalescent plasma therapy has shown a promising outcome against COVID-19 infection, as it did for infectious diseases. Although in COVID-19 variants of concern, convalescent plasma therapy showed a reduction in neutralization ~ 3-fold against P.1, and 7-13 folds against B.1.351 variant, it still can be used as a treatment for COVID-19 and its variants.

Abbreviations: PPE - personal protective equipment; VoC - Variants of concern; VoI - Variants of interest; CPT - convalescent plasma therapy; RBD - receptor-binding domain; ARDS - Acute Respiratory Distress Syndrome; ICU - Intensive Care Unit; IQR - Interquartile Range; RCT - Randomized Clinical Trial; RT-PCR - Reverse Transcriptase-Polymerase Chain Reaction; NAbs - neutralizing antibodies

Key words: Convalescent plasma therapy; COVID-19, Variants of Concern

Citation: Kurniawati EM, Putri IS, Widiatmaja DM, Praba VM, Visuddho 2, Prameswari FU, Zahrani M, Putra FN, Nugraha D, Widiastara AA. Effectiveness of convalescent plasma therapy for COVID-19 patients infected with variants of concerns. Anaesth. pain intensive care 2022;26(4):535-545; DOI: 10.35975/apic.v26i4.1962

Received: July 31, 2021; Reviewed: May 17, 2022; Accepted: May 18, 2022

Author Biographies

Eighty Mardiyan Kurniawati

Eighty Mardiyan Kurniawati, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Hospital, Surabaya, Indonesia

Innas Safira Putri

Innas Safira Putri, Medical Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Deandra Maharani Widiatmaja

Deandra Maharani Widiatmaja, Medical Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Venansya Maulina Praba

Venansya Maulina Praba, Medical Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Visuddho Visuddho

Visuddho Visuddho, Medical Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Faida Ufaira Prameswari

Faida Ufaira Prameswari, Medical Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Marsha Zahrani

Marsha Zahrani, Medical Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Felix Nugraha Putra

Felix Nugraha Putra, Medical Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

David Nugraha

David Nugraha, Medical Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Antonio Ayrton Widiastara

Antonio Ayrton Widiastara, Medical Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Published
08-21-2022
How to Cite
Kurniawati, E., Putri, I., Widiatmaja, D., Praba, V., Visuddho, V., Prameswari, F., Zahrani, M., Putra, F., Nugraha, D., & Widiastara, A. (2022). Effectiveness of convalescent plasma therapy for COVID-19 patients infected with variants of concerns. Anaesthesia, Pain & Intensive Care, 26(4), 535-545. https://doi.org/10.35975/apic.v26i4.1962
Section
NARRATIVE REVIEW

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